Fabiana Gámbaro Post-doc

Biographical sketch

Fabiana studied for a master’s degree in Molecular Biology at the University of the Republic, Uruguay (March 2016 - August 2018). For her master’s dissertation, she worked at Institut Pasteur of Montevideo, and her research focused on small regulatory RNAs, extracellular vesicles, and their role in cell-to-cell communication. Then, viruses won her over. So, for her PhD, she moved on to work on the epidemiology and evolution of RNA viruses such as SARS-CoV-2 and Chikungunya virus at the Institut Pasteur, Paris, France, under the supervision of Etienne Simon-Loriere (October 2018 – June 2022). In particular, during her Ph.D., she used NGS technologies to generate virus genomic data, which she analysed to study intra-host viral diversity or reconstruct viral outbreak dynamics and spatiotemporal spread using phylodynamic approaches. In October 2022, Fabiana joined the Spatial Epidemiology Lab for her first post-doc, where she works on testing and applying new landscape phylogeographic techniques.

Research interests

Fabiana’s research interests focus on investigating the epidemiology and evolution of RNA viruses and applying new phylodynamic approaches to understand how these processes interact. In particular, she is interested in using methods of spatiotemporal reconstruction of viral spread (landscape phylogeographic approaches) to understand the impact of environmental factors on the dispersal history and dynamic of viruses. Fabiana is also very interested in studying the evolution of RNA viruses operating at different scales: between and intra-host evolution.

External links: ResearchGate, Google Scholar

Publications

A novel SARS-CoV-2 related coronavirus in bats from Cambodia
D. Delaune, V. Hul, E. A. Karlsson, A. Hassanin, T. P. Ou, A. Baidaliuk, F. Gámbaro, M. Prot, V. T. Tu, S. Chea, L. Keatts, J. Mazet, C. K. Johnson, P. Buchy, P. Dussart, T. Goldstein, E. Simon-Lorière, and V. Duong. "Nature Communications", Vol. 12, Issue 1, Pages 6563, 2021.

Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015–2018
F. Gámbaro, A. B. Pérez, E. Agüera, M. Prot, L. Martínez-Martínez, M. Cabrerizo, E. Simon-Loriere, and M. D. Fernandez-Garcia. "Scientific Reports", Vol. 11, Issue 1, Pages 21523, 2021.

RI-SEC-seq: comprehensive profiling of nonvesicular extracellular RNAs with different stabilities
J. P. Tosar, F. Gámbaro, M. Castellano, and A. Cayota. "Bio-protocol", Vol. 11, Issue 4, Pages e3918-e3918, 2021.

Stable tRNA halves can be sorted into extracellular vesicles and delivered to recipient cells in a concentration-dependent manner
F. Gámbaro, M. Li Calzi, P. Fagúndez, B. Costa, G. Greif, E. Mallick, S. Lyons, P. Ivanov, K. Witwer, A. Cayota, and J. P. Tosar. "RNA Biology", Vol. 17, Issue 8, Pages 1168-1182, 2020.

Introductions and early spread of SARS-CoV-2 in France, 24 January to 23 March 2020
F. Gámbaro, S. Behillil, A. Baidaliuk, F. Donati, M. Albert, A. Alexandru, M. Vanpeene, M. Bizard, A. Brisebarre, M. Barbet, F. Derrar, S. v. d. Werf, V. Enouf, and E. Simon-Loriere. "Eurosurveillance", Vol. 25, Issue 26, Pages 2001200, 2020.

Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome
J. P. Tosar, M. Segovia, M. Castellano, F. Gámbaro, Y. Akiyama, P. Fagúndez, Á. Olivera, B. Costa, T. Possi, M. Hill, P. Ivanov, and A. Cayota. "Nucleic Acids Research", Vol. 48, Issue 22, Pages 12874-12888, 2020.

Dimerization confers increased stability to nucleases in 5′ halves from glycine and glutamic acid tRNAs
J. P. Tosar, F. Gámbaro, L. Darré, S. Pantano, E. Westhof, and A. Cayota. "Nucleic Acids Research", Vol. 46, Issue 17, Pages 9081-9093, 2018.

Evidence of increasing diversification of Zika virus strains isolated in the American continent
F. Aldunate, F. Gámbaro, A. Fajardo, M. Soñora, and J. Cristina. "Journal of Medical Virology", Vol. 89, Issue 12, Pages 2059-2063, 2017.

Naturally occurring NS3 resistance-associated variants in hepatitis C virus genotype 1: Their relevance for developing countries
N. Echeverría, G. Betancour, F. Gámbaro, N. Hernández, P. López, D. Chiodi, A. Sánchez, S. Boschi, A. Fajardo, M. Sóñora, G. Moratorio, J. Cristina, and P. Moreno. "Virus Research", Vol. 223, Pages 140-146, 2016.

Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines
J. P. Tosar, F. Gámbaro, J. Sanguinetti, B. Bonilla, K. W. Witwer, and A. Cayota. "Nucleic Acids Research", Vol. 43, Issue 11, Pages 5601-5616, 2015.